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KMID : 0988420010130040421
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Journal of Dental Science (C.N.U.)
2001 Volume.13 No. 4 p.421 ~ p.433
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The Effect of Calcium Sulfate - Bioactive Glass 45S5 Composite Graft and and with without Calcium Sulfate Membrane on Osseous Regeneration in Rabbit Mandibular Bone Defects
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Abstract
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The purpose of the present study was to investigate the effect of the composite grafts of calcium sulfate and bioactive glass 45S5 in combination with calcium sulfate barrier in the experimental bone defects. Twenty rabbits, weighing about 2.5kg, were used. Three artificial bone defects, 5×5×5㎣ in size, were made at the mandibular angle area. In the experimental group 1, the bone defect was filled with bioactive glass 45S5 and calcium sulfate; in the experimental group 2, the bone defect was filled with the composite graft of bioactive glass 45S5 and calcium sulfate and covered with calcium sulfate membrane barrier. In the control group, the bone defect was filled with blood and was spontaneously healed. The rabbits were sacrified at 1, 2, 4, 6 and 8 weeks after the operation. Microscopic examination was performed. The results obtained were as follows;
In the experimental group 1, prominent new bone formation was observed in compared with the control group. In the experimental group 2, extensive osseous regeneration was demonstrated in compared with the experimental group 1. The bioactive glass 45S5 were minutely cracked at week 2, and connective tissues were migrated into inner portion of the glass particles through the crack at week 4. As a consequence, each glass particles may function as a nucleation-site for new bone formation. As the experimental time elapsed, the amount of new bone formation was increased in the two experimental groups in compared with the control group.
These results suggest that the composite graft of bioactive glass 45S5 and calcium sulfate promote new bone formation, and the composite graft in combination with calcium sulfate barrier is considered as a potential method for osseous regeneration.
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